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讲师-助研

李娇娇
作者: 发布时间:2021-11-22 点击数:

Jiaojiao Li

Lecturer

42BA8

College of Ecology and Environmental Sciences, Yunnan University, Kunming, 650091, PR China.

Office: Building ShiXun 1501-7,YNU

Phone: 18088260774

Email: jiaojiaoli@ynu.edu.cn

WeChat: lp20100104

WeChat Public Nogh_9482afd572d5

QQ:2495594458 Tiktok No: dyycopqa4lle

Education

2012-2017 PhD: Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States. Major: Biomedical Sciences

2005-2010 MD: College of Clinical Medicine, Kunming Medical University, Kunming, Yunnan, China. Major: Clinical Medicine

Areas of interest/specialization

1. Environmental toxicology: this research contributions include identification and/or characterization of Secondary metabolites of cyanobacteria blooms, development ecotoxicology of Harmful Algal Blooms (HABs); process xenobiotics or endobiotics metabolism and detoxification pathway in human, animal, microbiome and plant.

2. Adverse outcome pathway: this research aims to identify and sequence the molecular and cellular events to evaluate the toxicity of specific environmental pollutants. Describe the progression of a toxicity pathway from molecular perturbation to cell to tissue to organ to organism to population-level outcome in a series of measurable, mechanistic responses.

Selected publications

1. Jiaojiao Li, Chunxiao Sun, Wenwen Cai, Barry P. Rosen, Jian Chen. Insights into S-adenosyl-L-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms. Mutation Research/Reviews in Mutation Research. 2021, 108396, ISSN 1383-5742, https://doi.org/10.1016/j.mrrev.2021.108396.

2. Li, J. J, L. Yang, C . P. Miao, Y. J. Teng, Z. H. Fu, C. L. Cheng, X. X. Chang, Y. Qian, and L. X. Zhao. 2021. Impact of rhizosphere microorganisms on arsenic (As) transformation and accumulation in a traditional Chinese medical plant. Environ Sci Pollut Res Int. 2021 Nov;28(43):60923-60934. doi: 10.1007/s11356-021-14500-6. Epub 2021 Jun 24. PMID: 34165739.

3. Jiaojiao LiCharles PackianathanToby G. RossmanBarry P. Rosen, Nonsynonymous Polymorphisms in the Human As3mt Arsenic Methylation Gene: Implications for Arsenic Toxicity, Chemical Research in Toxicology, 2017, 30 (7): 1481-1491.

4. Jiaojiao LiShashank S. PawitwarBarry P. Rosen, The Organoarsenical Biocycle and the Primordial Antibiotic Methylarsenite, Metallomics, 2016, 8 (10): 1047-1055.

5. Jiaojiao LiGoutam MandalBarry P. Rosen, Expression of Arsenic Resistance Genes in the Obligate Anaerobe Bacteroides Vulgatus Atcc 8482, a Gut Microbiome Bacterium, Anaerobe, 2016, 39: 117-123

Active grants

Project: Adverse outcome pathways of extracellular exudates of Cyanobacteria and its main component phytosphingosine

Role: Principal Investigator
Sponsor: National Natural Science Foundation of China
Period: Jan 2022– Dec 2024
Total Funding: ¥240,000
Status: Active

Project: Teratogenicity of tretinoids from cyanobacteria extracellular exudates.

Role: Principal Investigator
Sponsor: Science and Technology Department of Yunnan Province
Period: Jan 2021– Dec 2023
Total Funding: ¥50,000
Status: Active

姓 名:李娇娇 

性别:

籍 贯:云南大理 

生 日:19861207

政治面貌:中共党员(2006年至今)

信仰:共产主义

邮 箱: jiaojiaoli@ynu.edu.cnm15925168046@163.com

电话:18088260774

办公地:云南大学呈贡校区实训楼1501-7

目前就职: bet356亚洲版体育在线

职称:讲师

行政职务:2019年5月—2020年10月:生态与环境学院学生第一党支部,支部书记; 2019年7月至今:生态与环境学院研究生兼职辅导员。

教育背景

2012-2017硕博连读(PhD):美国佛罗里达国际大学医学院(HWCOM FIU) 生物医学专业(主要研究砷的代谢与解毒机制)

2005-2010 本科: 昆明医科大学, 临床医学专业五年

李娇娇,博士。本科(2005-2010年)毕业于昆明医科大学,临床医学专业。博士(硕博连读2012-2017年)毕业于美国佛罗里达国际大学,生物医学专业。本人PhD期间,发表SCI论文7篇,其中第一作者3篇,第二作者3篇。研究方向为砷的代谢、解毒机制。2017-2018年就职于大理大学基础医学院。2019年至今,就职于bet356亚洲版体育在线,生态毒理与环境健康研究团队(团队成员:常学秀、钱昱、徐润冰、黄婧老师)。2021年获批云南省科技厅、云南省教育厅科研项目,经费共计7万元。2022年获批国家自然科学基金,经费共计24万元。20192021年发表学术论文三篇,以云南大学为第一单位SCI一区论文2篇,三区1篇;发表教学论文两篇。 2019年,入选云南省千人计划青年人才专项。

主要研究方向:

研究方向主要为有害结局路径和效应导向分析集合下的环境毒理体系构建,以及蓝藻水华生态风险及防控。具体包括:(1)水华蓝藻胞外分泌物分离、鉴定;水华蓝藻次生代谢物在滇池金线鲃、大型溞等生物体内的有害结局路径分析。(2)特定环境污染物环境毒理基础上,通过细胞模型、机器学习、分子对接等工具,推动指定环境污染物在分子效应-细胞、组织、器官水平病理生理变化-个体反应-种群变化-群落组成-生态系统生态毒理效应普中的构建。

项目:

1)云南省科技厅, 应用基础研究青年项目, 铜绿微囊藻胞外分泌物中维A酸对滇池金线鲃胚胎的致畸性研究 202101AU070078, 2021-01 2023-12, 5 万元, 在研, 主持;

2)云南省教育厅, 科学研究基金教师类项目, 滇池铜绿微囊藻次生代谢物对滇池金线鲃胚胎的致畸性研究 2021J0003, 2021-01 2021-12, 2万元, 在研, 主持;

3)国家自然科学基金,水华蓝藻胞外分泌物及其主要成分植物鞘氨醇有害结局路径研究32101361 2022-01 2024-12 24万,在研,主持。

文章:

1. Jiaojiao Li*, Chunxiao Sun, Wenwen Cai, Barry P. Rosen, Jian Chen. Insights into S-adenosyl-L-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms. Mutation Research/Reviews in Mutation Research. 2021, 108396, ISSN 1383-5742, https://doi.org/10.1016/j.mrrev.2021.108396. (毒理学一区. 一作兼通讯作者)

2. Li, J. J.*, L. Yang, C . P. Miao, Y. J. Teng, Z. H. Fu, C. L. Cheng, X. X. Chang, Y. Qian, and L. X. Zhao. 2021. Impact of rhizosphere microorganisms on arsenic (As) transformation and accumulation in a traditional Chinese medical plant. Environ Sci Pollut Res Int. 2021 Nov;28(43):60923-60934. doi: 10.1007/s11356-021-14500-6. Epub 2021 Jun 24. PMID: 34165739. (SCI 三区)

3. Zhili Peng*Tianshu ZhaoYiqun ZhouShanghao LiJiaojiao Li*Roger M Leblanc*. Bone Tissue Engineering via Carbon‐based Nanomaterials. Advanced Healthcare Materials 2020, 9, 1901495. (SCI 一区,通讯作者)

4. Charles Packianathan, Jiaojiao Li, Palani Kandavelu, Banumathi Sankaran, and Barry P. Rosen*Reorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S‐Adenosylmethionine Methyltransferase ReactionACS Omega 2018, 3, 3104−3112.

5. Jiaojiao LiCharles PackianathanToby G. RossmanBarry P. Rosen, Nonsynonymous Polymorphisms in the Human As3mt Arsenic Methylation Gene: Implications for Arsenic Toxicity, Chemical Research in Toxicology, 2017, 30 (7): 1481-1491 IF=3.529)封面文章 doi: 10.1021/acs.chemrestox.7b00113.

6. Jiaojiao LiGoutam MandalBarry P. Rosen, Expression of Arsenic Resistance Genes in the Obligate Anaerobe Bacteroides Vulgatus Atcc 8482, a Gut Microbiome Bacterium, Anaerobe, *2016, 39: 117-123 IF=2.479doi: 10.1016/j.anaerobe.2016.03.012.

7. Jiaojiao LiShashank S. PawitwarBarry P. Rosen, The Organoarsenical Biocycle and the Primordial Antibiotic Methylarsenite, Metallomics, 2016, 8 (10): 1047-1055 IF=3.585doi: 10.1039/c6mt00168h.

8. Zhili Peng, Jiaojiao Li, Shanghao Li, Joel Pardo, Yiqun Zhou, Abdulrahman O. Al-Youbi,Abdulaziz S. Bashammakh, Mohammad S. El-Shahawi, Roger M. Leblanc, Quantification of Nucleic Acid Concentration in the Nanoparticle or Polymer Conjugates Using Circular Dichroism Spectroscopy, Analytical Chemistry, 2018, 90 (3): 2255-2262 IF=5.636doi: 10.1021/acs.analchem.7b04621.

9. Charles Packianathan, Jiaojiao Li, Palani Kandavelu, Banumathi Sankaran, and Barry P. RosenReorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S‐Adenosylmethionine Methyltransferase ReactionACS Omega 2018, 3, 3104−3112.

doi: 10.1021/acsomega.8b00197.

10. Jian ChenJiaojiao LiXuan JiangBarry P. Rosen, Conserved Cysteine Residues Determine Substrate Specificity in a Novel as(Iii) S-Adenosylmethionine Methyltransferase from Aspergillus Fumigatus, Molecular Microbiology, 2017, 104 (2): 250-259 IF=4.419

doi: 10.1111/mmi.13628.

目前承担的课程:

本科生课程:《环境学概论》《污染生态学》《阅读计划》(以上课程传承自生态与环境学院常学秀、刘嫦娥、常军军、段昌群、王焕校、耿宇鹏等老师)及《环境与健康》

研究生课程:《工程伦理》

招生要求:

本科生:态度认真,主动学习。

研究生:为人,有理想、有原则;做事,有思考力、更有执行力。

学生寄语:愿你们永远不会长大,但每天都在成长。要相信当你决定做一件正能量的事情时,全世界都会帮你!









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